Inflammatory cell burden and phenotype in endomyocardial biopsies with antibody-mediated rejection (AMR): a multicenter pilot study from the AECVP.
Identifieur interne : 000027 ( Main/Exploration ); précédent : 000026; suivant : 000028Inflammatory cell burden and phenotype in endomyocardial biopsies with antibody-mediated rejection (AMR): a multicenter pilot study from the AECVP.
Auteurs : M. Fedrigo [Italie] ; O. Leone ; M M Burke ; A. Rice ; C. Toquet ; D. Vernerey ; A-C Frigo ; R. Guillemain ; S. Pattier ; J. Smith ; A. Lota ; L. Potena ; A. Bontadini ; C. Ceccarelli ; F. Poli ; G. Feltrin ; G. Gerosa ; E. Manzan ; G. Thiene ; P. Bruneval ; A. Angelini ; J-P Duong Van HuyenSource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Anticorps (immunologie), Biopsie (MeSH), Complément C4b (métabolisme), Donneurs de tissus (MeSH), Europe (MeSH), Femelle (MeSH), Fragments peptidiques (métabolisme), Humains (MeSH), Incidence (MeSH), Inflammation (anatomopathologie), Myocardite (anatomopathologie), Mâle (MeSH), Phénotype (MeSH), Projets pilotes (MeSH), Rejet du greffon (anatomopathologie), Rejet du greffon (immunologie), Rejet du greffon (épidémiologie), Transplantation cardiaque (MeSH), Vaisseaux capillaires (anatomopathologie), Vaisseaux capillaires (métabolisme), Études cas-témoins (MeSH), Études rétrospectives (MeSH).
- MESH :
- anatomopathologie : Inflammation, Myocardite, Rejet du greffon, Vaisseaux capillaires.
- immunologie : Anticorps, Rejet du greffon.
- métabolisme : Complément C4b, Fragments peptidiques, Vaisseaux capillaires.
- épidémiologie : Rejet du greffon.
- Adulte, Adulte d'âge moyen, Biopsie, Donneurs de tissus, Europe, Femelle, Humains, Incidence, Mâle, Phénotype, Projets pilotes, Transplantation cardiaque, Études cas-témoins, Études rétrospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Antibodies (immunology), Biopsy (MeSH), Capillaries (metabolism), Capillaries (pathology), Case-Control Studies (MeSH), Complement C4b (metabolism), Europe (MeSH), Female (MeSH), Graft Rejection (epidemiology), Graft Rejection (immunology), Graft Rejection (pathology), Heart Transplantation (MeSH), Humans (MeSH), Incidence (MeSH), Inflammation (pathology), Male (MeSH), Middle Aged (MeSH), Myocarditis (pathology), Peptide Fragments (metabolism), Phenotype (MeSH), Pilot Projects (MeSH), Retrospective Studies (MeSH), Tissue Donors (MeSH).
- MESH :
- chemical , immunology : Antibodies.
- chemical , metabolism : Peptide Fragments.
- geographic : Europe.
- epidemiology : Graft Rejection.
- immunology : Graft Rejection.
- metabolism : Capillaries, Complement C4b.
- pathology : Capillaries, Graft Rejection, Inflammation, Myocarditis.
- Adult, Biopsy, Case-Control Studies, Female, Heart Transplantation, Humans, Incidence, Male, Middle Aged, Phenotype, Pilot Projects, Retrospective Studies, Tissue Donors.
Abstract
This multicenter case-controlled pilot study evaluated myocardial inflammatory burden (IB) and phenotype in endomyocardial biopsies (EMBs) with and without pathologic antibody-mediated rejection (pAMR). Sixty-five EMBs from five European heart transplant centers were centrally reviewed as positive (grade 2, n = 28), suspicious (grade 1, n = 7) or negative (n = 30) for pAMR. Absolute counts of total, intravascular (IV) and extravascular (EV) immunophenotyped mononuclear cells were correlated with pAMR grade, capillary C4d deposition, donor specific antibody (DSA) status and acute cellular rejection (ACR). In pAMR+ biopsies, equivalent number of IV CD3+ T lymphocytes (23 ± 4/0.225 mm(2) ) and CD68+ macrophages (21 ± 4/0.225 mm(2) ) were seen. IB and cell phenotype correlated with pAMR grade, C4d positivity and DSA positivity (p < 0.0001). High numbers of IV T lymphocytes were associated with low grade ACR (p = 0.002). In late-occurring AMR EV plasma cells occurring in 34% of pAMR+ EMBs were associated with higher IB. The IB in AMR correlated with pAMR+, C4d positivity and DSA positivity. In pAMR+ equivalent numbers of IV T lymphocytes and macrophages were found. The presence of plasma cells was associated with a higher IB and occurrence of pAMR late after transplantation.
DOI: 10.1111/ajt.12976
PubMed: 25612500
Affiliations:
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Le document en format XML
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Leone</name></author><author><name sortKey="Burke, M M" sort="Burke, M M" uniqKey="Burke M" first="M M" last="Burke">M M Burke</name></author><author><name sortKey="Rice, A" sort="Rice, A" uniqKey="Rice A" first="A" last="Rice">A. Rice</name></author><author><name sortKey="Toquet, C" sort="Toquet, C" uniqKey="Toquet C" first="C" last="Toquet">C. Toquet</name></author><author><name sortKey="Vernerey, D" sort="Vernerey, D" uniqKey="Vernerey D" first="D" last="Vernerey">D. Vernerey</name></author><author><name sortKey="Frigo, A C" sort="Frigo, A C" uniqKey="Frigo A" first="A-C" last="Frigo">A-C Frigo</name></author><author><name sortKey="Guillemain, R" sort="Guillemain, R" uniqKey="Guillemain R" first="R" last="Guillemain">R. Guillemain</name></author><author><name sortKey="Pattier, S" sort="Pattier, S" uniqKey="Pattier S" first="S" last="Pattier">S. Pattier</name></author><author><name sortKey="Smith, J" sort="Smith, J" uniqKey="Smith J" first="J" last="Smith">J. Smith</name></author><author><name sortKey="Lota, A" sort="Lota, A" uniqKey="Lota A" first="A" last="Lota">A. Lota</name></author><author><name sortKey="Potena, L" sort="Potena, L" uniqKey="Potena L" first="L" last="Potena">L. Potena</name></author><author><name sortKey="Bontadini, A" sort="Bontadini, A" uniqKey="Bontadini A" first="A" last="Bontadini">A. Bontadini</name></author><author><name sortKey="Ceccarelli, C" sort="Ceccarelli, C" uniqKey="Ceccarelli C" first="C" last="Ceccarelli">C. Ceccarelli</name></author><author><name sortKey="Poli, F" sort="Poli, F" uniqKey="Poli F" first="F" last="Poli">F. Poli</name></author><author><name sortKey="Feltrin, G" sort="Feltrin, G" uniqKey="Feltrin G" first="G" last="Feltrin">G. Feltrin</name></author><author><name sortKey="Gerosa, G" sort="Gerosa, G" uniqKey="Gerosa G" first="G" last="Gerosa">G. Gerosa</name></author><author><name sortKey="Manzan, E" sort="Manzan, E" uniqKey="Manzan E" first="E" last="Manzan">E. 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Angelini</name></author><author><name sortKey="Duong Van Huyen, J P" sort="Duong Van Huyen, J P" uniqKey="Duong Van Huyen J" first="J-P" last="Duong Van Huyen">J-P Duong Van Huyen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1111/ajt.12976</idno><idno type="RBID">pubmed:25612500</idno><idno type="pmid">25612500</idno><idno type="wicri:Area/PubMed/Corpus">000012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000012</idno><idno type="wicri:Area/PubMed/Curation">000012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000012</idno><idno type="wicri:Area/PubMed/Checkpoint">000007</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000007</idno><idno type="wicri:Area/Ncbi/Merge">000369</idno><idno type="wicri:Area/Ncbi/Curation">000369</idno><idno type="wicri:Area/Ncbi/Checkpoint">000369</idno><idno type="wicri:Area/Main/Merge">000027</idno><idno type="wicri:Area/Main/Curation">000027</idno><idno type="wicri:Area/Main/Exploration">000027</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammatory cell burden and phenotype in endomyocardial biopsies with antibody-mediated rejection (AMR): a multicenter pilot study from the AECVP.</title><author><name sortKey="Fedrigo, M" sort="Fedrigo, M" uniqKey="Fedrigo M" first="M" last="Fedrigo">M. Fedrigo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Leone, O" sort="Leone, O" uniqKey="Leone O" first="O" last="Leone">O. Leone</name></author><author><name sortKey="Burke, M M" sort="Burke, M M" uniqKey="Burke M" first="M M" last="Burke">M M Burke</name></author><author><name sortKey="Rice, A" sort="Rice, A" uniqKey="Rice A" first="A" last="Rice">A. Rice</name></author><author><name sortKey="Toquet, C" sort="Toquet, C" uniqKey="Toquet C" first="C" last="Toquet">C. Toquet</name></author><author><name sortKey="Vernerey, D" sort="Vernerey, D" uniqKey="Vernerey D" first="D" last="Vernerey">D. Vernerey</name></author><author><name sortKey="Frigo, A C" sort="Frigo, A C" uniqKey="Frigo A" first="A-C" last="Frigo">A-C Frigo</name></author><author><name sortKey="Guillemain, R" sort="Guillemain, R" uniqKey="Guillemain R" first="R" last="Guillemain">R. Guillemain</name></author><author><name sortKey="Pattier, S" sort="Pattier, S" uniqKey="Pattier S" first="S" last="Pattier">S. Pattier</name></author><author><name sortKey="Smith, J" sort="Smith, J" uniqKey="Smith J" first="J" last="Smith">J. Smith</name></author><author><name sortKey="Lota, A" sort="Lota, A" uniqKey="Lota A" first="A" last="Lota">A. Lota</name></author><author><name sortKey="Potena, L" sort="Potena, L" uniqKey="Potena L" first="L" last="Potena">L. Potena</name></author><author><name sortKey="Bontadini, A" sort="Bontadini, A" uniqKey="Bontadini A" first="A" last="Bontadini">A. Bontadini</name></author><author><name sortKey="Ceccarelli, C" sort="Ceccarelli, C" uniqKey="Ceccarelli C" first="C" last="Ceccarelli">C. Ceccarelli</name></author><author><name sortKey="Poli, F" sort="Poli, F" uniqKey="Poli F" first="F" last="Poli">F. Poli</name></author><author><name sortKey="Feltrin, G" sort="Feltrin, G" uniqKey="Feltrin G" first="G" last="Feltrin">G. Feltrin</name></author><author><name sortKey="Gerosa, G" sort="Gerosa, G" uniqKey="Gerosa G" first="G" last="Gerosa">G. Gerosa</name></author><author><name sortKey="Manzan, E" sort="Manzan, E" uniqKey="Manzan E" first="E" last="Manzan">E. Manzan</name></author><author><name sortKey="Thiene, G" sort="Thiene, G" uniqKey="Thiene G" first="G" last="Thiene">G. Thiene</name></author><author><name sortKey="Bruneval, P" sort="Bruneval, P" uniqKey="Bruneval P" first="P" last="Bruneval">P. Bruneval</name></author><author><name sortKey="Angelini, A" sort="Angelini, A" uniqKey="Angelini A" first="A" last="Angelini">A. Angelini</name></author><author><name sortKey="Duong Van Huyen, J P" sort="Duong Van Huyen, J P" uniqKey="Duong Van Huyen J" first="J-P" last="Duong Van Huyen">J-P Duong Van Huyen</name></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Antibodies (immunology)</term><term>Biopsy (MeSH)</term><term>Capillaries (metabolism)</term><term>Capillaries (pathology)</term><term>Case-Control Studies (MeSH)</term><term>Complement C4b (metabolism)</term><term>Europe (MeSH)</term><term>Female (MeSH)</term><term>Graft Rejection (epidemiology)</term><term>Graft Rejection (immunology)</term><term>Graft Rejection (pathology)</term><term>Heart Transplantation (MeSH)</term><term>Humans (MeSH)</term><term>Incidence (MeSH)</term><term>Inflammation (pathology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Myocarditis (pathology)</term><term>Peptide Fragments (metabolism)</term><term>Phenotype (MeSH)</term><term>Pilot Projects (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Tissue Donors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Anticorps (immunologie)</term><term>Biopsie (MeSH)</term><term>Complément C4b (métabolisme)</term><term>Donneurs de tissus (MeSH)</term><term>Europe (MeSH)</term><term>Femelle (MeSH)</term><term>Fragments peptidiques (métabolisme)</term><term>Humains (MeSH)</term><term>Incidence (MeSH)</term><term>Inflammation (anatomopathologie)</term><term>Myocardite (anatomopathologie)</term><term>Mâle (MeSH)</term><term>Phénotype (MeSH)</term><term>Projets pilotes (MeSH)</term><term>Rejet du greffon (anatomopathologie)</term><term>Rejet du greffon (immunologie)</term><term>Rejet du greffon (épidémiologie)</term><term>Transplantation cardiaque (MeSH)</term><term>Vaisseaux capillaires (anatomopathologie)</term><term>Vaisseaux capillaires (métabolisme)</term><term>Études cas-témoins (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptide Fragments</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Inflammation</term><term>Myocardite</term><term>Rejet du greffon</term><term>Vaisseaux capillaires</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps</term><term>Rejet du greffon</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Capillaries</term><term>Complement C4b</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complément C4b</term><term>Fragments peptidiques</term><term>Vaisseaux capillaires</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Capillaries</term><term>Graft Rejection</term><term>Inflammation</term><term>Myocarditis</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Rejet du greffon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biopsy</term><term>Case-Control Studies</term><term>Female</term><term>Heart Transplantation</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Pilot Projects</term><term>Retrospective Studies</term><term>Tissue Donors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biopsie</term><term>Donneurs de tissus</term><term>Europe</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Phénotype</term><term>Projets pilotes</term><term>Transplantation cardiaque</term><term>Études cas-témoins</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This multicenter case-controlled pilot study evaluated myocardial inflammatory burden (IB) and phenotype in endomyocardial biopsies (EMBs) with and without pathologic antibody-mediated rejection (pAMR). Sixty-five EMBs from five European heart transplant centers were centrally reviewed as positive (grade 2, n = 28), suspicious (grade 1, n = 7) or negative (n = 30) for pAMR. Absolute counts of total, intravascular (IV) and extravascular (EV) immunophenotyped mononuclear cells were correlated with pAMR grade, capillary C4d deposition, donor specific antibody (DSA) status and acute cellular rejection (ACR). In pAMR+ biopsies, equivalent number of IV CD3+ T lymphocytes (23 ± 4/0.225 mm(2) ) and CD68+ macrophages (21 ± 4/0.225 mm(2) ) were seen. IB and cell phenotype correlated with pAMR grade, C4d positivity and DSA positivity (p < 0.0001). High numbers of IV T lymphocytes were associated with low grade ACR (p = 0.002). In late-occurring AMR EV plasma cells occurring in 34% of pAMR+ EMBs were associated with higher IB. The IB in AMR correlated with pAMR+, C4d positivity and DSA positivity. In pAMR+ equivalent numbers of IV T lymphocytes and macrophages were found. The presence of plasma cells was associated with a higher IB and occurrence of pAMR late after transplantation.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Angelini, A" sort="Angelini, A" uniqKey="Angelini A" first="A" last="Angelini">A. Angelini</name><name sortKey="Bontadini, A" sort="Bontadini, A" uniqKey="Bontadini A" first="A" last="Bontadini">A. Bontadini</name><name sortKey="Bruneval, P" sort="Bruneval, P" uniqKey="Bruneval P" first="P" last="Bruneval">P. Bruneval</name><name sortKey="Burke, M M" sort="Burke, M M" uniqKey="Burke M" first="M M" last="Burke">M M Burke</name><name sortKey="Ceccarelli, C" sort="Ceccarelli, C" uniqKey="Ceccarelli C" first="C" last="Ceccarelli">C. Ceccarelli</name><name sortKey="Duong Van Huyen, J P" sort="Duong Van Huyen, J P" uniqKey="Duong Van Huyen J" first="J-P" last="Duong Van Huyen">J-P Duong Van Huyen</name><name sortKey="Feltrin, G" sort="Feltrin, G" uniqKey="Feltrin G" first="G" last="Feltrin">G. Feltrin</name><name sortKey="Frigo, A C" sort="Frigo, A C" uniqKey="Frigo A" first="A-C" last="Frigo">A-C Frigo</name><name sortKey="Gerosa, G" sort="Gerosa, G" uniqKey="Gerosa G" first="G" last="Gerosa">G. Gerosa</name><name sortKey="Guillemain, R" sort="Guillemain, R" uniqKey="Guillemain R" first="R" last="Guillemain">R. Guillemain</name><name sortKey="Leone, O" sort="Leone, O" uniqKey="Leone O" first="O" last="Leone">O. Leone</name><name sortKey="Lota, A" sort="Lota, A" uniqKey="Lota A" first="A" last="Lota">A. Lota</name><name sortKey="Manzan, E" sort="Manzan, E" uniqKey="Manzan E" first="E" last="Manzan">E. Manzan</name><name sortKey="Pattier, S" sort="Pattier, S" uniqKey="Pattier S" first="S" last="Pattier">S. Pattier</name><name sortKey="Poli, F" sort="Poli, F" uniqKey="Poli F" first="F" last="Poli">F. Poli</name><name sortKey="Potena, L" sort="Potena, L" uniqKey="Potena L" first="L" last="Potena">L. Potena</name><name sortKey="Rice, A" sort="Rice, A" uniqKey="Rice A" first="A" last="Rice">A. Rice</name><name sortKey="Smith, J" sort="Smith, J" uniqKey="Smith J" first="J" last="Smith">J. Smith</name><name sortKey="Thiene, G" sort="Thiene, G" uniqKey="Thiene G" first="G" last="Thiene">G. Thiene</name><name sortKey="Toquet, C" sort="Toquet, C" uniqKey="Toquet C" first="C" last="Toquet">C. Toquet</name><name sortKey="Vernerey, D" sort="Vernerey, D" uniqKey="Vernerey D" first="D" last="Vernerey">D. Vernerey</name></noCountry><country name="Italie"><noRegion><name sortKey="Fedrigo, M" sort="Fedrigo, M" uniqKey="Fedrigo M" first="M" last="Fedrigo">M. Fedrigo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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